DuPrey has nearly a decade of self-producing her own solo shows. Her critically-acclaimed work includes SEXomedy, SUSHI-frito, SEXomedy 2.0: The Second Coming, and the upcoming piece completing the solo trilogy, Good Grief. Her full-length play Brujaja is currently in development and is slated to have a world premiere at UrbanTheater Company. All of her work can be read or commissioned through The New Play Exchange. 

Regional Theatre credits include: For Colored Girls (Court Theater), The Compass (Steppenwolf Theatre) and Luna Gale (Goodman Theatre). Other theatre credits include Tilikum (Sideshow Theater Company), Good Friday (Oracle Theater), American Beauty Shop (Chicago Dramatist), SUSHI-frito (Free Street Theatre), Adoration of the Old Woman (Urban Theatre Company), and A Citizen’s Anthology (Inconvenience Theatre). 

Melissa has also been hired as an artistic curator and producer of multiple showcases, full-length play productions, and new work festivals with Pegasus Theater, Free Street Theater, UrbanTheater Company, The Breathing Room, and Teatro Luna.